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Compared with mouse thymocytes, mouse ES cells comprise increased levels of total genomic H3K4me3 and have higher H3K4me3 occupancy at the promoter of the pluripotent gene Oct4 forty six In settlement with this, international decreases in H3K4me3 ranges occur throughout retinoic acid (RA)-induced differentiation of mouse ES cells 47 In addition, there are dynamic changes in H3K4me3 profiles at particular sets of genes during ES cell differentiation.

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